Welcome to the Gestwicki Laboratory at UCSF! 

We are interested in how molecular chaperones, such as Hsp70 and Hsp90, work together to maintain protein homeostasis, which is the balance of protein folding, trafficking and turnover. Understanding this delicate balance is important because protein homeostasis is dramatically disrupted in many diseases, especially neurodegeneration and cancer. Our approach is to create small molecules that disrupt (or promote) interactions between chaperones. Using these chemical probes, we perturb protein-protein interactions and learn how this chaperone network is "wired". These studies have taken us into many exciting areas of biotechnology and chemical biology. Please see the Publications section for a list of our recent work and check out the People section to see the fantastic team we have assembled around these ideas.